The project “ Novel Mg-Ca-Zn biodegradable metallic materials used in orthopedic applications ” proposes the elaboration of biodegradable materials from the Mg-0.5Ca-xZn system for use in medical implantology. In the last decade, many researchers have made progress on biodegradable Mg-based alloys with applications in medicine. The unique chemical composition of these alloys offers all the premises of promising results regarding bone regeneration and the elimination of the 2nd surgery. The use of these elements leads to a considerable increase in corrosion resistance, biocompatibility and mechanical properties. The project has a strong multidisciplinary character, due to the complexity of the the studies will focus on testing this class of biodegradable materials through microstructural analysis (OM, SEM and XRD), tribological tests, electrochemical behavior in SBF, cell viability tests (in vitro analysis –MTT method) and in vivo analysis on laboratory model animals. These results will contribute to the certification of the preliminary information obtained and the confirmation of the controlled and biocompatible biodegradable character of the Mg-0.5Ca-xZn alloys used in orthopedics. The project aims to identify an optimum concentration of the Mg-0.5Ca-xZn system, to publish the results in international journals with ISI impact factor, to submit the patent documentation and to identify the users and manufacturers of biocompatible materials for the technological transfer.
The main objective of the project is obtaining new Mg-0.5Ca-xZn biodegradable materials with superior properties, verified by in vitro/in vivo analysis in order to be approved for usage as orthopedic implants. The production of such implants would contribute significantly to the development of orthopedic domain using biodegradable materials that are absorbed into the biological body by contributing to bone tissue regeneration. It is extremely important to respect all quality standards from alloys manufacturing in controlled atmosphere till in vitro/in vivo testing in specific cellular medium, respectively on laboratory animals, using standard protocols from the domain.
Conf.univ.dr.ing.
Istrate Bogdan
TUIASI
Prof.univ.dr.ing
Cimpoesu Nicanor
TUIASI
Conf.univ.dr.ing.
Benchea Marcelin
TUIASI
Sef.lucr.dr.ing.
Bălțatu Madălina-Simona
TUIASI
Dr. Bioinginer
Cojocaru Florina-Daniela
UMF IAȘI
Asist.univ.dr.ing.
Lupescu Ștefan-Constantin
TUIASI
Sef.lucr.dr.ing.
Cimpoesu Ramona
TUIASI
Sef Lucrari dr. bioing.
Bălan Vera
UMF IAȘI
Dr. medic veterinar
Henea Mădălina
USV IAȘI